Biotechnology for Healthy Ageing

Call UE del programma Horizon Europe (HORIZON), bando "EIC Pathfinder Challenges 2026" (HORIZON-EIC-2026-PATHFINDERCHALLENGES-01). Tipo di azione: HORIZON EIC Grants. Stato: aperta. Prossima scadenza: 28/10/2026 (single-stage). Testo ufficiale (in inglese): Scope: Ageing, the gradual decline of organismal homeostasis and of physiologic functions throughout the body and mind, is a critical shared risk factor for many ageing-related chronic diseases. The EU also has an ageing society - by 2050, the share of 85+ year-olds in the EU is expected to ​more than double​, but extended life expectancy is not ​matched with years spent in good health, which ​currently stands at 70.5 years. This will present significant social, economic and healthcare challenges and thus calls for interventions that will promote healthy longevity, as well as tools that will enable the adoption of these interventions. Over the past decades basic research has identified hallmarks and cellular mechanisms of ageing, creating the basis for biotechnology-based or pharmaceutical therapeutic interventions, such as targeting cellular maintenance pathways, stem cell exhaustion, cellular senescence or metabolic fitness. Nonetheless, translating these insights into clinical interventions has had a low success rate, partially due to the difficulty of:​ Translating approaches from model systems Identifying when to intervene Rigorous validation, and End-to-end considerations of implementation (i.e. the delivery of an…